What is Renal Failure?
Kidneys help filter waste from the blood. Therefore renal failure, also known as kidney failure, is a condition in which the kidney can no longer adequately filter and balance fluids. As internal waste builds up, the condition can causes weakness, shortness of breath, lethargy and psychological confusion. Because potassium can remain dangerously in the bloodstream, the heart may begin to murmur abnormally. And in some cases, sudden death occurs.
Controlling one’s blood pressure and diabetes can help prevent kidney failure, but with age kidney functionality gradually weakens. A blood test will identify renal failure. Once found, treatments will aim to balance fluids, control potassium and restore calcium levels. Although the condition is often degenerative, kidney failure can be reversible through transplant or dialysis.
How can Celltex stem cell therapy help?
Several studies in pre-clinical animal models have suggested that mesenchymal stem cells may provide therapeutic benefit for acute kidney injury and renal failure. Although the mechanisms are not completely understood, some studies have shown that through secretion of angiogenic and trophic factors, as well as immunomodulatory factors, mesenchymal stem cells can promote renal protective effects. Some studies have also shown through proliferation and survival of glomerular and tubular cells. Transplantation of Mesenchymal Stem Cells in humans for a variety of conditions has been generally well tolerated, although results have been variable as a function of delivery route and the potency of cells between donors, tissue sources and culture conditions has been well documented.
Research articles on the use of stem cells in the treatment of kidney injury and renal failure:
Examples of current and completed clinical trials registered at FDA.gov that investigate use of Mesenchymal Stem Cells: