What is COPD?
Chronic Obstructive Pulmonary Disease, or COPD, is a chronic inflammatory lung condition that causes restricted airflow from the lungs.
When you breathe, air travels down the trachea and into the lungs through two tubes called bronchi, which divide into many smaller tubes that end in tiny air sacs called alveoli. The elastic nature of both the bronchi and alveoli helps to force air out of your body during respiration, but COPD causes them to lose their elasticity, which can trap air in the lungs during exhalation.
By far, the most common cause of COPD is smoking, but respiratory conditions such as Emphysema and chronic Bronchitis can contribute to COPD.
COPD is quite treatable, and with proper management, most people can gain control over their symptoms and achieve a good quality of life.
How can Celltex stem cell therapy help?
The airways of COPD patients exhibit a high level expression of inflammatory factors, including Interleukin (IL)-1β, IL-6, IL-8, and tumor necrosis factor (TNF)-α. Many immune cells such as T cells, B cells, natural killer cells, neutrophils are present in the airway, contributing to mucous hypersecretion, alveolar destruction and emphysema. Injected MSCs home to the injured airways, and release multiple anti-inflammatory factors and growth factors, such as IL-10, VEG, VEGFR2, FGF-2 and angiopoietin-1. These cytokines inhibit cell apoptosis and cell death and decrease oxidative stress of lung tissues. Some studies have demonstrated that angiopoietin-1 plays an important role in stabilizing endotoxin-induced endothelial fluid leaks and maintaining alveolar-capillary barrier function.
Stem cell therapies are actively being explored for COPD because of their ability to modulate the immune system in the alveoli of the lungs to halt damage and promote repair. An example clinical trial (2013) using allogeneic mesenchymal stem cells demonstrated safety of IV infused cells, and certain patients showed a reduction in systemic inflammation markers (http://www.ncbi.nlm.nih.gov/pubmed/23172272). Transplantation of Mesenchymal stem cells in humans for a variety of conditions has to date, been generally well tolerated.
Research articles on use of stem cells in COPD can be found here:
Examples of current and completed clinical trials registered at FDA.gov can be found here:
Examples of clinical trials registered at FDA.gov (current and completed) investigating steam cells to treat emphysema can be found here: