What is a cardiovascular disease?
Cardiovascular disease is the leading cause of death in the United States. The condition includes any disease that attacks the functions of the heart and blood vessels including coronary heart disease, heart attack, congestive heart failure, and congenital heart disease, arrhythmia and stroke. Many forms of cardiovascular disease stem from atherosclerosis, the hardening of the arteries via plaque formation, and any number of things that can cause a heart attack such as high blood pressure, obesity, smoking, and diabetes.
While each type of cardiovascular disease has numerous symptoms, the most common direct indication is a heart attack. Heart attacks occur when blood flow to the heart is blocked. This is often characterized by intense pain in the chest, arm or below the breastbone. Long-term doctors recommend healthy lifestyle changes to prevent further heart damage. To lower one’s odds of heart disease, it is important to quit smoking and lower cholesterol levels. To do so, doctors recommend avoiding trans fats and saturated fats and eating a large variety of nutrient-rich foods.
How can Celltex stem cell therapy help?
Given their immunomodulatory, anti-inflammatory, and potential regenerative properties, mesenchymal stem cells (MSCs) hold promise in the treatment of Cardiovascular Disease. From pre-clinical studies, there is some evidence that injected MSCs can engraft into heart tissue and potentially differentiate into cardiomyocytes (native muscle cells of the heart). There is greater evidence for an alternative mechanism, namely where MSCs can activate cells within the heart via their paracrine function (ability to secrete agents that can reach neighboring cells, including cytokines as well as particles called exosomes). Numerous preclinical studies have shown that MSCs may stimulate new blood vessel formation (angiogenesis) reduce fibrosis, and promote formation of new heart tissue leading to improvements in structure and function of remodeled ventricles. While there is now significant preclinical and clinical evidence that MSCs are safe and exhibit restorative effects for treatment of cardiovascular disease, the precise mechanisms are not well understood. Transplantation of MSCs in humans for a variety of conditions has been generally well tolerated.
Research articles on use of stem cells in the treatments of Cardiovascular Disease can be found here:
Examples of current and completed clinical trials registered at FDA.gov that investigate use of mesenchymal stem cells can be found here: