Researchers in Korea have discovered that adult mesenchymal stem cells (MSCs) may help to reduce inflammation in mice suffering from Lupus. The discovery came after researchers injected mice suffering from systemic lupus erythematosus (SLE), an autoimmune disease that produces immune reactions which leads to a variety of symptoms including kidney inflammation or nephritis, with adult stem cells derived from human bone marrow. The mice injected with these MSCs experienced a reduction in inflammation as well as attenuated nephritis. The injection of MSCs worked to slow the progression of lupus nephritis by suppressing T helper cells (Tfh), which are damaging antibodies in SLE. Dr. Maria Carolina de Oliveira Rodrigues of the University of Sao Paulo, Brazil says, “Stem cell therapy is an attractive treatment option in that it is associated with fewer side effects than pharmacotherapy and, as the researchers suggested, it may actually slow the progression of the disease rather than merely alleviate symptom severity.”
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